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Machine Learning

A collection of articles and resources on clinical applications of machine learning.

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RESEARCH

Original Investigation

External Validation of a Widely Implemented Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, MD, Erkin Otles, MEng et al.

Research Letter

Global Media Coverage of the Benefits and Harms of Early Detection Tests

Mary O’Keeffe, PhD, Alexandra Barratt, MD et al.

Original Investigation

Concordance Between Blood Pressure in SPRINT and in Routine Clinical Practice

Paul E. Drawz, MD, MHS, MS, Anil Agarwal, MD et al.

Original Investigation

Detection of Pathogenic Variants With Germline Genetic Testing in Patients With Prostate Cancer and Melanoma

Saud H. AlDubayan, MD, Jake R. Conway, BSc et al.

Research Letter

Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms

Amit Kaushal, MD, PhD, Russ Altman, MD, PhD et al.

Preliminary Communication

Effect of a Machine Learning–Derived Early Warning System vs Standard Care on Hypotension During Noncardiac Surgery

Marije Wijnberge, MD, Bart F. Geerts, MD, PhD, MSc, MBA et al.

Research Letter

Automatically Charting Symptoms From Patient-Physician Conversations Using Machine Learning

Alvin Rajkomar, MD, Anjuli Kannan, AB et al.

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches

Thomas H. McCoy Jr, MD, Roy H. Perlis, MD, MSc

Original Investigation

Machine Learning Screen for Diabetic Retinopathy and Other Eye Diseases

Daniel Shu Wei Ting, MD, PhD, Carol Yim-Lui Cheung, PhD et al.

Original Investigation

Machine Learning Detection of Breast Cancer Lymph Node Metastases

Babak Ehteshami Bejnordi, MS, Mitko Veta, PhD et al.

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REVIEW

Users' Guides to the Medical Literature

How to Read Articles That Use Machine Learning

Yun Liu, PhD, Po-Hsuan Cameron Chen, PhD et al.

JAMA Guide to Statistics and Methods

On Deep Learning for Medical Image Analysis

Lawrence Carin, PhD, Michael J. Pencina, PhD

OPINION

Viewpoint

Preparing Clinicians for a Clinical World Influenced by Artificial Intelligence

Cornelius A. James, MD, Robert M. Wachter, MD et al.

Viewpoint

Proactive vs Reactive Machine Learning in Health Care

Yuan Luo, PhD, Richard G. Wunderink, MD et al.

Viewpoint

Preventing Digital Overdiagnosis

Daniel Capurro, MD, PhD, Simon Coghlan, PhD et al.

Viewpoint

Next-Generation Artificial Intelligence for Diagnosis

Julia Adler-Milstein, PhD, Jonathan H. Chen, MD, PhD et al.

Viewpoint

Modernizing Public Health Data Systems

Kushal T. Kadakia, MSc, Michael D. Howell, MD, MPH et al.

Editorial

Importance of External Validation in Sepsis

Anand R. Habib, MD, MPhil, Anthony L. Lin, MD et al.

Viewpoint

Leveraging the Medicare Program for a COVID-19 Vaccination Campaign

Nicole Lurie, MD, MSPH, Bettina Experton, MD, MPH

Invited Commentary

A Tale of 2 Blood Pressures

John A. Dodson, MD, MPH, Daichi Shimbo, MD

Viewpoint

Navigating Through Healthcare Data Disrupted by the COVID-19 Pandemic

Kayoko Shioda, DVM, MPH, Daniel M. Weinberger, PhD et al.

Editorial

Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics

W. Gregory Feero, MD, PhD

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SPECIALTY MACHINE LEARNING
Cardiology
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Challenges During Implementation of Clinical Decision Support Systems JAMA Network Open |
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
Leveraging Large Clinical Data Sets for Artificial Intelligence in Medicine JAMA Cardiology |
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SPECIALTY MACHINE LEARNING
Dermatology
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
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SPECIALTY MACHINE LEARNING
Cardiology
Dermatology
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Effect of Clinical Decision Support at Community Health Centers on CVD Risk JAMA Network Open |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Challenges During Implementation of Clinical Decision Support Systems JAMA Network Open |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
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Neurology
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Performance of Machine Learning Algorithms for Predicting Progression to Dementia JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Brain Electrical Activity–Based Index to Aid in Diagnosing Concussion Among Athletes JAMA Network Open |
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Oncology
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
Maximizing Cancer Data—The Future of Cancer Is Now JAMA Oncology |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Generative Adversarial Networks for Oncological Applications JAMA Oncology |
Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer JAMA Network Open |
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Neurology
Oncology
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Maximizing Cancer Data—The Future of Cancer Is Now JAMA Oncology |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Generative Adversarial Networks for Oncological Applications JAMA Oncology |
Performance of Machine Learning Algorithms for Predicting Progression to Dementia JAMA Network Open |
Racial Disparities in COVID-19 Outcomes Among Black and White Patients With Cancer JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Brain Electrical Activity–Based Index to Aid in Diagnosing Concussion Among Athletes JAMA Network Open |
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Ophthalmology
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
Artificial Intelligence–Based Guidance During Phacoemulsification Cataract Surgery JAMA Ophthalmology |
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Otolaryngology
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Ophthalmology
Otolaryngology
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Predicting Emergency Department Use and Unplanned Hospitalization in Patients With Head and Neck Cancer JAMA Otolaryngology–Head & Neck Surgery |
Artificial Intelligence for Screening of Multiple Retinal and Optic Nerve Diseases JAMA Network Open |
A Deep Learning Approach to Predict Conductive Hearing Loss in Patients With Otitis Media With Effusion JAMA Otolaryngology–Head & Neck Surgery |
Accessibility Requests Using Electronic Health Record–Based Questionnaire JAMA Network Open |
Artificial Intelligence in Clinical Practice Is Here JAMA Ophthalmology |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Detecting Glaucoma in the Ocular Hypertension Study Using Deep Learning JAMA Ophthalmology |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Artificial Intelligence–Based Guidance During Phacoemulsification Cataract Surgery JAMA Ophthalmology |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
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Pediatrics
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Assessing the Value of Artificial Intelligence in Retinopathy of Prematurity Screening JAMA Ophthalmology |
Expediting Care in Pediatric Emergency Medicine With Machine Learning Medical Directives JAMA Network Open |
Use of Machine Learning and Statistical Techniques to Adjust for Nonadherence in RCTs JAMA Network Open |
Use of Machine Learning to Estimate Effect of Low-Dose Aspirin on Pregnancy Outcomes JAMA Network Open |
Calculator for Pediatric Low-Value Care in US Children’s Hospitals JAMA Network Open |
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Psychiatry
Analysis of Access to Prescription Data Management Programs Data for Research JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Comparison of Methods to Reduce Bias From Clinical Prediction Models of Postpartum Depression JAMA Network Open |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
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Pediatrics
Psychiatry
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
A Deep Learning Model to Predict the Occurrence and Severity of Retinopathy of Prematurity JAMA Network Open |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Cost-effectiveness of Artificial Intelligence–Based Retinopathy of Prematurity Screening JAMA Ophthalmology |
Use of Machine Learning and Statistical Techniques to Adjust for Nonadherence in RCTs JAMA Network Open |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Calculator for Pediatric Low-Value Care in US Children’s Hospitals JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
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Surgery
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Distinct Subtypes of Black Kidney Transplant Recipients JAMA Surgery |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity JAMA Network Open |
An Artificial Intelligence–Powered Platform for Prostate Cancer Grading and Quantification JAMA Network Open |
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Radiology
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Artificial Intelligence in Medical Imaging JAMA Health Forum |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
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Surgery
Radiology
Machine Learning Algorithms for Detecting Traumatic Intracranial Hemorrhage JAMA Network Open |
Deep Learning Model to Screen for Trisomy 21 During the First Trimester JAMA Network Open |
Deep Learning for Nuchal Translucency–Based Screening for Fetal Trisomy 21 JAMA Network Open |
Explainable Machine Learning Model for Major Complications After Cytoreductive Surgery JAMA Network Open |
Distinct Subtypes of Black Kidney Transplant Recipients JAMA Surgery |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Machine Learning–Based Risk Stratification for Chronic Limb-Threatening Ischemia JAMA Network Open |
Artificial Intelligence in Medical Imaging JAMA Health Forum |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity JAMA Network Open |
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Original Investigation

Factors Correlated With Satisfaction With Mobile Health Apps for Weight Loss

Tong Wang, BS, Xu Zheng, BS et al.

JAMA Network Open |

Original Investigation

Social Mission Commitment at Dental, Medical, and Nursing Schools in the US

Sonal Batra, MD, MST, Julie Orban, MPH et al.

JAMA Network Open |

Research Letter

Perspectives of Patients About Artificial Intelligence in Health Care

Dhruv Khullar, MD, MPP, Lawrence P. Casalino, MD, PhD et al.

JAMA Network Open |

Research Letter

Reducing Hospital Employees’ Unauthorized Access to Protected Health Information

John Xuefeng Jiang, PhD, Nick Culbertson, BS et al.

JAMA Network Open |

Original Investigation

Default Order vs EHR Alert to Increase HCV Screening Among Hospitalized Patients

Shivan J. Mehta, MD, MBA, MSHP, Jessie Torgersen, MD, MHS, MSCE et al.

JAMA Network Open |

Original Investigation

Net Worth and Ambulatory Blood Pressure in Early Middle-aged African American Women

Telisa Spikes, PhD, Raphiel Murden, PhD et al.

JAMA Network Open |

Invited Commentary

Digital Health Emergency Management

Lennart Reifels, PhD, Virginia Murray, MBBS, MSc

JAMA Network Open |

Consensus Statement

Implementing Digital Health to Ensure Global Health Security During Pandemics

Bandar Al Knawy, MD, Mollie Marian McKillop, MPH et al.

JAMA Network Open |

JAMA Forum

Overuse and Underuse of Health Care: New Insights From Economics and Machine Learning

Katherine Baicker, PhD, Ziad Obermeyer, MD

JAMA Health Forum |

Original Investigation

Translatability of NIH-Funded Biomedical Research That Applies Artificial Intelligence

Feyisope R. Eweje, SB, Suzie Byun, SB et al.

JAMA Network Open |
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