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Machine Learning

A collection of articles and resources on clinical applications of machine learning.

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RESEARCH

Original Investigation

External Validation of a Widely Implemented Sepsis Prediction Model in Hospitalized Patients

Andrew Wong, MD, Erkin Otles, MEng et al.

Research Letter

Global Media Coverage of the Benefits and Harms of Early Detection Tests

Mary O’Keeffe, PhD, Alexandra Barratt, MD et al.

Original Investigation

Concordance Between Blood Pressure in SPRINT and in Routine Clinical Practice

Paul E. Drawz, MD, MHS, MS, Anil Agarwal, MD et al.

Original Investigation

Detection of Pathogenic Variants With Germline Genetic Testing in Patients With Prostate Cancer and Melanoma

Saud H. AlDubayan, MD, Jake R. Conway, BSc et al.

Research Letter

Geographic Distribution of US Cohorts Used to Train Deep Learning Algorithms

Amit Kaushal, MD, PhD, Russ Altman, MD, PhD et al.

Preliminary Communication

Effect of a Machine Learning–Derived Early Warning System vs Standard Care on Hypotension During Noncardiac Surgery

Marije Wijnberge, MD, Bart F. Geerts, MD, PhD, MSc, MBA et al.

Research Letter

Automatically Charting Symptoms From Patient-Physician Conversations Using Machine Learning

Alvin Rajkomar, MD, Anjuli Kannan, AB et al.

Research Letter

Temporal Trends and Characteristics of Reportable Health Data Breaches

Thomas H. McCoy Jr, MD, Roy H. Perlis, MD, MSc

Original Investigation

Machine Learning Screen for Diabetic Retinopathy and Other Eye Diseases

Daniel Shu Wei Ting, MD, PhD, Carol Yim-Lui Cheung, PhD et al.

Original Investigation

Machine Learning Detection of Breast Cancer Lymph Node Metastases

Babak Ehteshami Bejnordi, MS, Mitko Veta, PhD et al.

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REVIEW

Users' Guides to the Medical Literature

How to Read Articles That Use Machine Learning

Yun Liu, PhD, Po-Hsuan Cameron Chen, PhD et al.

JAMA Guide to Statistics and Methods

On Deep Learning for Medical Image Analysis

Lawrence Carin, PhD, Michael J. Pencina, PhD

OPINION

Viewpoint

Preventing Digital Overdiagnosis

Daniel Capurro, MD, PhD, Simon Coghlan, PhD et al.

Viewpoint

Next-Generation Artificial Intelligence for Diagnosis

Julia Adler-Milstein, PhD, Jonathan H. Chen, MD, PhD et al.

Viewpoint

Modernizing Public Health Data Systems

Kushal T. Kadakia, MSc, Michael D. Howell, MD, MPH et al.

Editorial

Importance of External Validation in Sepsis

Anand R. Habib, MD, MPhil, Anthony L. Lin, MD et al.

Viewpoint

Leveraging the Medicare Program for a COVID-19 Vaccination Campaign

Nicole Lurie, MD, MSPH, Bettina Experton, MD, MPH

Viewpoint

Navigating Through Healthcare Data Disrupted by the COVID-19 Pandemic

Kayoko Shioda, DVM, MPH, Daniel M. Weinberger, PhD et al.

Invited Commentary

A Tale of 2 Blood Pressures

John A. Dodson, MD, MPH, Daichi Shimbo, MD

Editorial

Bioinformatics, Sequencing Accuracy, and the Credibility of Clinical Genomics

W. Gregory Feero, MD, PhD

Viewpoint

Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies

Stephanie Eaneff, MSP, Ziad Obermeyer, MD et al.

Viewpoint

AI-Assisted Conversational Agents in Health Care—Clinical, Legal, and Ethical Aspects

John D. McGreevey III, MD, C. William Hanson III, MD et al.

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SPECIALTY MACHINE LEARNING
Cardiology
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
Leveraging Large Clinical Data Sets for Artificial Intelligence in Medicine JAMA Cardiology |
Use of Machine Learning Models to Predict Death After Myocardial Infarction JAMA Cardiology |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Finding New Meaning in Everyday Electrocardiograms JAMA Cardiology |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Machine Learning and Dispatcher Recognition of Out-of-Hospital Cardiac Arrest JAMA Network Open |
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SPECIALTY MACHINE LEARNING
Dermatology
Checklist for Evaluation of Image-Based Artificial Intelligence Reports in Dermatology JAMA Dermatology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
Patient Perspectives on the Use of Artificial Intelligence for Skin Cancer Screening JAMA Dermatology |
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SPECIALTY MACHINE LEARNING
Cardiology
Dermatology
Convolutional Neural Network With Explainability for 12-Lead ECGs JAMA Cardiology |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Leveraging Large Clinical Data Sets for Artificial Intelligence in Medicine JAMA Cardiology |
Lack of Transparency and Potential Bias in AI Data Sets and Algorithms JAMA Dermatology |
Use of Machine Learning Models to Predict Death After Myocardial Infarction JAMA Cardiology |
Risk of Bias and Error From Data Sets Used for Dermatologic AI JAMA Dermatology |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Clinical Evaluation of Artificial Intelligence–Based Digital Wound Assessment Tools JAMA Network Open |
Finding New Meaning in Everyday Electrocardiograms JAMA Cardiology |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Machine Learning and Dispatcher Recognition of Out-of-Hospital Cardiac Arrest JAMA Network Open |
Patient Perspectives on the Use of Artificial Intelligence for Skin Cancer Screening JAMA Dermatology |
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Neurology
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Performance of Machine Learning Algorithms for Predicting Progression to Dementia JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Brain Electrical Activity–Based Index to Aid in Diagnosing Concussion Among Athletes JAMA Network Open |
Burden of Neurological Disorders Across the US From 1990-2017 JAMA Neurology |
Social Norm Email Feedback Program and Unnecessary Prescription of Nimodipine in Older Adults JAMA Network Open |
Trends in Cervical Spine Curvature Assessed by Deep Learning System Segmentation JAMA Network Open |
Machine Learning Prediction of Treatment Response to Antidepressants JAMA Network Open |
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Oncology
Preventing Digital Overdiagnosis JAMA |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait JAMA Network Open |
Evaluation of an AI–Augmented Digital System for Histologic Classification of Colorectal Polyps JAMA Network Open |
An Artificial Intelligence–Powered Platform for Prostate Cancer Grading and Quantification JAMA Network Open |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
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Neurology
Oncology
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Preventing Digital Overdiagnosis JAMA |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Performance of Machine Learning Algorithms for Predicting Progression to Dementia JAMA Network Open |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait JAMA Network Open |
Brain Electrical Activity–Based Index to Aid in Diagnosing Concussion Among Athletes JAMA Network Open |
Evaluation of an AI–Augmented Digital System for Histologic Classification of Colorectal Polyps JAMA Network Open |
Burden of Neurological Disorders Across the US From 1990-2017 JAMA Neurology |
An Artificial Intelligence–Powered Platform for Prostate Cancer Grading and Quantification JAMA Network Open |
Social Norm Email Feedback Program and Unnecessary Prescription of Nimodipine in Older Adults JAMA Network Open |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Trends in Cervical Spine Curvature Assessed by Deep Learning System Segmentation JAMA Network Open |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
Machine Learning Prediction of Treatment Response to Antidepressants JAMA Network Open |
Global Media Coverage of the Benefits and Harms of Early Detection Tests JAMA Internal Medicine |
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Ophthalmology
Artificial Intelligence–Based Guidance During Phacoemulsification Cataract Surgery JAMA Ophthalmology |
Real-time Augmented Reality—The Next Frontier for Ophthalmic Surgery JAMA Ophthalmology |
Machine Learning–Based Anomaly Detection Techniques in Ophthalmology JAMA Ophthalmology |
Pivotal Evaluation of an Artificial Intelligence System for Detection of Diabetic Retinopathy JAMA Network Open |
Deep Learning–Based Automated OCT Segmentation in Clinical Routine JAMA Ophthalmology |
Whole-Volume Automated Segmentation of OCT in Retinal Disease Using Deep Learning JAMA Ophthalmology |
Automated Retinal Fluid Volume Quantification JAMA Ophthalmology |
Using Artificial Intelligence to Identify Serious Retinopathy of Prematurity JAMA Network Open |
Multidimensional Deep Learning Platform for Retinopathy of Prematurity Screening JAMA Network Open |
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Otolaryngology
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Use of Deep Learning to Analyze Social Media Discussions About the HPV Vaccine JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
Machine Learning Model to Help Predict Survival Among Patients With OSCC JAMA Otolaryngology–Head & Neck Surgery |
Using Laryngectomies to Help Voice Concerns About Health Care Databases JAMA Otolaryngology–Head & Neck Surgery |
Formal Idiographic Inference in Medicine JAMA Otolaryngology–Head & Neck Surgery |
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Ophthalmology
Otolaryngology
Artificial Intelligence–Based Guidance During Phacoemulsification Cataract Surgery JAMA Ophthalmology |
Deep Learning for Clinical Image Analyses in Oral Squamous Cell Carcinoma JAMA Otolaryngology–Head & Neck Surgery |
Real-time Augmented Reality—The Next Frontier for Ophthalmic Surgery JAMA Ophthalmology |
Deep Learning to Augment Image-Guided Radiotherapy for Head and Neck and Prostate Cancers JAMA Network Open |
Machine Learning–Based Anomaly Detection Techniques in Ophthalmology JAMA Ophthalmology |
Machine Learning–Guided Adjuvant Treatment of Head and Neck Cancer JAMA Network Open |
Pivotal Evaluation of an Artificial Intelligence System for Detection of Diabetic Retinopathy JAMA Network Open |
Machine Learning Model for Survival Risk Stratification in Advanced Oral Cancer JAMA Network Open |
Deep Learning–Based Automated OCT Segmentation in Clinical Routine JAMA Ophthalmology |
Automated Mandibular Movement Monitoring for Obstructive Sleep Apnea JAMA Network Open |
Whole-Volume Automated Segmentation of OCT in Retinal Disease Using Deep Learning JAMA Ophthalmology |
Machine Learning by Ultrasonography for Genetic Risk Stratification JAMA Otolaryngology–Head & Neck Surgery |
Automated Retinal Fluid Volume Quantification JAMA Ophthalmology |
Machine Learning Model to Help Predict Survival Among Patients With OSCC JAMA Otolaryngology–Head & Neck Surgery |
Using Artificial Intelligence to Identify Serious Retinopathy of Prematurity JAMA Network Open |
Using Laryngectomies to Help Voice Concerns About Health Care Databases JAMA Otolaryngology–Head & Neck Surgery |
Multidimensional Deep Learning Platform for Retinopathy of Prematurity Screening JAMA Network Open |
Formal Idiographic Inference in Medicine JAMA Otolaryngology–Head & Neck Surgery |
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Pediatrics
Calculator for Pediatric Low-Value Care in US Children’s Hospitals JAMA Network Open |
Mortality and Cause of Death Among Youths Previously Incarcerated in the Juvenile Legal System JAMA Network Open |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait JAMA Network Open |
Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge JAMA Network Open |
Using Artificial Intelligence to Identify Serious Retinopathy of Prematurity JAMA Network Open |
Multidimensional Deep Learning Platform for Retinopathy of Prematurity Screening JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
Respiratory Function in Children Wearing Face Masks During the COVID-19 Pandemic JAMA Network Open |
Effect of Clinical Decision Support on Diagnostic Imaging for Pediatric Appendicitis JAMA Network Open |
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Psychiatry
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Comparison of Methods to Reduce Bias From Clinical Prediction Models of Postpartum Depression JAMA Network Open |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
Prediction, Not Association, Paves the Road to Precision Medicine JAMA Psychiatry |
Multimodal Machine Learning Workflows for Prediction of Psychosis JAMA Psychiatry |
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Pediatrics
Psychiatry
Calculator for Pediatric Low-Value Care in US Children’s Hospitals JAMA Network Open |
Computational Psychiatry Across Species to Study the Biology of Hallucinations JAMA Psychiatry |
Mortality and Cause of Death Among Youths Previously Incarcerated in the Juvenile Legal System JAMA Network Open |
Machine Learning–Based Deep Phenotyping of Atopic Dermatitis JAMA Dermatology |
Prediction of Posttraumatic Stress Disorder and Depression After a Motor Vehicle Collision JAMA Psychiatry |
Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait JAMA Network Open |
Comparison of Methods to Reduce Bias From Clinical Prediction Models of Postpartum Depression JAMA Network Open |
Influenza Vaccination Among Hospitalized Children Before Inpatient Discharge JAMA Network Open |
Using Artificial Intelligence to Identify Serious Retinopathy of Prematurity JAMA Network Open |
Nonphysician Diagnosis and Triage in Case Vignettes Before and After Internet Search JAMA Network Open |
Multidimensional Deep Learning Platform for Retinopathy of Prematurity Screening JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
Machine Learning Assessment of Early Life Factors Predicting Suicide Attempt JAMA Network Open |
Respiratory Function in Children Wearing Face Masks During the COVID-19 Pandemic JAMA Network Open |
Prediction, Not Association, Paves the Road to Precision Medicine JAMA Psychiatry |
Effect of Clinical Decision Support on Diagnostic Imaging for Pediatric Appendicitis JAMA Network Open |
Multimodal Machine Learning Workflows for Prediction of Psychosis JAMA Psychiatry |
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Surgery
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity JAMA Network Open |
An Artificial Intelligence–Powered Platform for Prostate Cancer Grading and Quantification JAMA Network Open |
Deep Learning to Automate Technical Skills Assessment in Robotic Surgery JAMA Surgery |
Ethical Issues Posed by AI Intraoperative Decision Support JAMA Surgery |
A 3-D Convolutional Neural Network for Automatic Surgical Skill Assessment JAMA Network Open |
Equity and Artificial Intelligence in Surgical Care JAMA Surgery |
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Radiology
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
Deep Learning Model to Quantify IFTA From Kidney Ultrasonography Images JAMA Network Open |
Deep Convolutional Neural Networks to Diagnose Scaphoid Fractures JAMA Network Open |
Deep Convolutional Neural Networks to Identify Scaphoid Fractures in Radiographs JAMA Network Open |
Effect of Clinical Decision Support on Diagnostic Imaging for Pediatric Appendicitis JAMA Network Open |
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Surgery
Radiology
Patient-Specific Kidney Transplant Function and Sequence-to-Sequence Deep Learning Model JAMA Network Open |
Analysis of Routine CT Scans With Radiomics and Machine Learning JAMA Oncology |
Advances in Postoperative Triage and the Role of Real-time Machine-Learning Models JAMA Network Open |
Artificial Intelligence–Based Chest X-ray Model on Human Nodule Detection Accuracy JAMA Network Open |
Association of Postoperative Undertriage to Hospital Wards With Mortality and Morbidity JAMA Network Open |
Data Set and Deep Learning Algorithm for Analyzing Digital Breast Tomosynthesis Images JAMA Network Open |
An Artificial Intelligence–Powered Platform for Prostate Cancer Grading and Quantification JAMA Network Open |
Data Quality, Data Sharing, and Moving Artificial Intelligence Forward JAMA Network Open |
Deep Learning to Automate Technical Skills Assessment in Robotic Surgery JAMA Surgery |
Deep Learning Model to Quantify IFTA From Kidney Ultrasonography Images JAMA Network Open |
Ethical Issues Posed by AI Intraoperative Decision Support JAMA Surgery |
Deep Convolutional Neural Networks to Diagnose Scaphoid Fractures JAMA Network Open |
A 3-D Convolutional Neural Network for Automatic Surgical Skill Assessment JAMA Network Open |
Deep Convolutional Neural Networks to Identify Scaphoid Fractures in Radiographs JAMA Network Open |
Equity and Artificial Intelligence in Surgical Care JAMA Surgery |
Effect of Clinical Decision Support on Diagnostic Imaging for Pediatric Appendicitis JAMA Network Open |
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Wearable Sensors to Detect Influenza and the Common Cold Before Symptom Onset

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Prevalence of Third-Party Data Tracking by US Hospital Websites

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Diagnostic Errors, Health Disparities, and Artificial Intelligence

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A Machine Learning Triage Tool for Risk of Death After Emergency Admission

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Telemedicine for Specialty Care in North Carolina Correctional Facilities

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